Leelamine hydrochloride ( Dehydroabietylamine )

Catalog No. M12521 CAS No. 16496-99-4

Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR).

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

Leelamine hydrochloride
Note

Research use only, not for human use.
Brief Description

Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR).
Description

Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR), inhibits castration-resistant prostate cancer cells; causes apoptosis and suppresses 22Rv1 xenograft growth in vivo; Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.
Synonyms

Dehydroabietylamine
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

——
Indication

——

Chemical Information

CAS Number

16496-99-4
Formula Weight

321.93
Molecular Formula

C20H32ClN
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C.Cl
Chemical Name

1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Singh KB, et al. Mol Cancer Ther. 2018 Jul 20. pii: molcanther.0117.2018.
2. Gowda R, et al. Oncotarget. 2017 Apr 25;8(17):28260-28277.
3. Sehrawat A, et al. Mol Carcinog. 2017 Feb;56(2):337-348.
4. Kuzu OF, et al. Mol Cancer Ther. 2014 Jul;13(7):1690-703.

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